Cerebral Hemodynamics and Cerebrospinal Fluid Flow in the Presence of Choroid Plexus Papilloma

Quantification of the cerebrospinal fluid (CSF) system may be useful for distinguishing relative treatments in the presence of choroid plexus papillomas (CPPs). To study the CSF system, mathematical models and simulations detailing the cerebral blood flow and CSF filtration were constructed to represent a normal brain, a brain with CPP located in the left lateral ventricle, and a brain with CPP located in the fourth ventricle. Furthermore, analysis of treatments by implementing a shunt for each experimental case were assessed. Flow distributions and intracranial pressures were obtained to assess the severity of each condition and the effectiveness of the shunt treatments. The results show that when CPP grows in the LLV or in the 4V, the ICP grows uncontrollably. When the shunt is applied to the LLV, the shunt is most effective after about 40% CPP growth. When the shunt is applied to the 4V, the shunt is effective from the very onset of CPP growth.